PD-1 AND TIGIT COEXPRESSION IDENTIFIES A CIRCULATING CD8 T CELL SUBSET PREDICTIVE OF RESPONSE TO ANTI-PD-1 THERAPY

PD-1 and TIGIT coexpression identifies a circulating CD8 T cell subset predictive of response to anti-PD-1 therapy

Background Clinical benefit from programmed cell death 1 receptor (PD-1) inhibitors relies on reinvigoration of endogenous antitumor immunity.Nonetheless, robust immunological markers, based on circulating immune cell subsets associated with therapeutic efficacy are yet to be validated.Methods We isolated peripheral blood mononuclear cell from thre

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Model Komunikasi Antarbudaya Etnik Madura dan Etnik Melayu

This study aims to determine the model of intercultural communication and intercultural communication barriers between Madurese and Malays in Roban, Singkawang West Kalimantan.It is research a qualitative research.Data were collected through observation, document review, and interviews.The result shows that the form of communication is mutual respe

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Recruitment of Baltic cod and sprat stocks: identification of critical life stages and incorporation of environmental variability into stock-recruitment relationships

The recruitment processes of Baltic cod and sprat were analysed and critical periods were identified by addressing the major impact factors on individual early life history stages separately and relating observed abundance data between successive stages.For cod, recruitment appeared to be dependent on egg survival, with low oxygen concentration in

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